The connection anywhere between BMD and you may weight are stronger than anywhere between Body mass index and BMD

The connection anywhere between BMD and you may weight are stronger than anywhere between Body mass index and BMD

step 3.step three. Exposure Activities

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Both Bmi and you may weight was correlated that have BMD, and BMC indications together with strongest Pearson’s relationship coefficients was basically located ranging from weight and you will BMC overall hip and you may trochanter regions and you will the fresh weakest of those was anywhere between Body mass index and you may femoral shoulder BMC. The brand new correlations between many years and BMD and BMC evidence was indeed bad (Table 4).

Age-adjusted proportion regarding BMD and you can BMC variation informed me by the Bmi and you will weight try revealed inside the Table 5. Pounds had a tendency to tell you deeper differences in BMD and BMC shipping whatsoever the latest examined skeletal websites compared to the Body mass index. This is mirrored of the steeper hill (?) of your respective linear regression traces. The number one difference in BMD and you may BMC delivery seemed from the trochanter BMC accompanied by lumbar BMC for pounds. Lbs is a vital predictor from BMD and you can BMC variation into the elderly Iranian people.

cuatro. Conversation

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The latest mechanisms whereby fatty tissue exerts positive effects on BMD status are not entirely clear. The latest putative mechanism benefits out-of adipose tissue to own skeletal ethics most likely stays in the latest character of a lot adipokines when you look at the bones remodeling thanks to impact on one another creation and resorption. Has just, bones has been noticed an endocrine organ impacting fat manage and you can sugar homoeostasis from the methods regarding limbs-derived activities for example osteocalcin and you may osteopontin [23, 34–36]. The newest putative crosstalk anywhere between body weight additionally the bones comprises an effective homoeostatic views system where adipokines and you can particles produced from the osteoblasts and you will osteoclasts portray the hyperlink from a working bones-adipose axis [34–36]. Being obese is also associated with BMD by conversion process of androgen in order to the hormone estrogen , and that enhances limbs mass in folk [38, 39] and you may preserves compliment plasma amounts of insulin and you can regulating things and insulin-instance increases basis-step one, leptin, and you will adiponectin . On the other hand, carrying excess fat provides padding towards hip in the event of an excellent fall . go to the website Yet not, the mechanisms by which a few of these incidents exist will always be uncertain.

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